Cleaved collagen type II fibril Collagen type II fibril Collagen type II degradation by MMP1,3,8,13,PRSS2 Authored: Jupe, S, 2011-07-12 EC Number: 3.4.21 Edited: Jupe, S, 2012-11-12 MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996, Mitchell et al. 1996, Billinghurst et al. 1997) known in the literature as collagenases I, II and III respectively are able to digest the intrahelical bonds of collagen type II, cleaving between amino acids Gly975 and Leu976 of the Uniprot canonical sequence. Human trypsin-2 is also capable of cleaving the triple helix of human cartilage collagen type II (Stenman et al. 2005). Pubmed16192646 Pubmed2005102 Pubmed3038863 Pubmed6270089 Pubmed8576151 Pubmed8609233 Pubmed9119997 Reactome Database ID Release 431474197 Reactome, http://www.reactome.org ReactomeREACT_150223 Reviewed: Sorsa, Timo, 2012-10-08