MT-MMPs MT-MMPs MT-MMPs are sorted to the plasma membrane Authored: Jupe, S, 2011-09-09 Edited: Jupe, S, 2012-02-21 Pubmed10036228 Pubmed11773076 Pubmed11830519 Pubmed8621565 Pubmed8804434 Reactome Database ID Release 431605825 Reactome, http://www.reactome.org ReactomeREACT_118753 Reviewed: Butler, GS, 2012-02-28 Reviewed: Overall, CM, 2012-02-28 The process that targets activated MT-MMPs to the plasma membrane is unclear but presumed to involve standard golgi transport mechanisms. The cytoplasmic domain of MT1-MMP is critical for the localization to discrete regions of the cell surface (Urena et al. 1999) and involved in internalization which has a regulatory role. The cytoplasmic domain mediates interactions with specific cell-surface proteins such as C1Q binding protein which may serve to direct the MMP from the golgi to the cell surface (Rozanov et al. 2002).