Cleaved collagen type I fibril Collagen type I fibril Collagen type I degradation by MMP1,2,8,13, PRSS2 Authored: Jupe, S, 2011-07-12 EC Number: 3.4.21 Edited: Jupe, S, 2012-11-12 MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996) known in the literature as collagenases I, II and III respectively are able to digest the intrahelical bonds of collagen type I. MMP2, also known as Gelatinase-A, was found to cleave collagen type I fibrils (Aimes & Quigley 1995). Though this was disputed (Seltzre & Eisen 1999) there is a structural explanation for the apparent discrepancies in experimental data (Patterson et al. 2001). In addition trypsin-2 is able to degrade native soluble type I collagen (Moilanen et al. 2003). Degradation is represented here at a theoretical end point where every alpha strand has been cleaved. Pubmed10383752 Pubmed11513874 Pubmed12731883 Pubmed15257288 Pubmed3038863 Pubmed6270089 Pubmed7790374 Pubmed7890717 Pubmed8576151 Reactome Database ID Release 431454822 Reactome, http://www.reactome.org ReactomeREACT_150397 Reviewed: Sorsa, Timo, 2012-10-08