Fibrillins MFAP2, MFAP5 Fibrilins:MFAP2,MFAP5 MFAP2, MFAP5 bind microfibrils Authored: Jupe, S, 2012-04-30 Edited: Jupe, S, 2012-11-12 Microfibrils are composed largely of fibrillin but also contain covalently-linked microfibril associated glycoproteins MAGP-1 (MFAP2) and MAGP-2 (MFAP5). MFAP2 is a structural component of almost all vertebrate microfibrils (Gibson et al. 1989, Trask et al. 2000, Jensen et al. 2001). It appears to be important for tissue development and/or homeostasis, including regulation of bone remodelling and deposition of tissue fat (Weinbaum et al. 2008). The C-terminal half of MFAP2 is rich in cysteines and contains a matrix-binding domain that facilitates interactions with fibrillin (Weinbaum et al. 2008). The related MFAP5 similarly binds to microfibrils (Gibson et al. 1998) but with a restricted expression profile. Pubmed10793130 Pubmed11481325 Pubmed18625713 Pubmed2647740 Pubmed9671438 Reactome Database ID Release 432129385 Reactome, http://www.reactome.org ReactomeREACT_150448 Reviewed: Muiznieks, Lisa, 2012-11-02