Collagen alpha-1(XXV) ectodomains Cleaved collagen type XXV Collagen type XXV Collagen type XXV ectomain shedding Authored: Jupe, S, 2011-07-12 EC Number: 3.4.21 Edited: Jupe, S, 2012-11-12 Identified as a component of amyloid plaques in Alzheimer's brain, the ectodomain of type XXV collagen (known as CLAC) is released by furin convertase activity (Hashimoto et al. 2002). The presence of CLAC leads to Abeta fibril bundles that have an increased resistance to proteases (Söderberg et al. 2005). Pubmed11927537 Pubmed15615705 Pubmed15853808 Reactome Database ID Release 432471842 Reactome, http://www.reactome.org ReactomeREACT_150355 Reviewed: Sorsa, Timo, 2012-10-08 has a Stoichiometric coefficient of 3