Cleaved collagen type IX Collagen type IX Collagen type IX degradation by MMP3,13 Authored: Jupe, S, 2011-07-12 EC Number: 3.4.21 Edited: Jupe, S, 2012-11-12 Pubmed11212149 Pubmed2005102 Pubmed2027130 Pubmed2920840 Pubmed3609327 Pubmed9065415 Pubmed9363632 Reactome Database ID Release 431564184 Reactome, http://www.reactome.org ReactomeREACT_150281 Reviewed: Sorsa, Timo, 2012-10-08 Type IX collagen interacts covalently with type II collagen fibril surfaces, suggesting that it represents a macromolecular bridge between fibrils and other cartilage matrix components (Eyre et al. 1987, Olsen 1997). Degradation of type IX (and type II) collagen is seen at the onset of inflammatory arthritis (Kojima et al. 2001). <br><br>Collagen type IX is cleaved by MMP3 (Okada et al. 1989, Eyre et al. 1991, Wu et al. 1991) and MMP13 (Knauper et al. 1997).