Sema4D:pPlexin-B1:Met Sema4D:pPlexin-B1:Met:RAC1-GTP Active Rac1 interacts with Plexin-B1:Sema4D Active Rac1 interacts with Plexin-B1:Sema4A Authored: Garapati, P V, 2009-03-23 09:59:28 Edited: Garapati, P V, 2009-03-23 10:00:07 Pubmed11035813 Pubmed11937491 Reactome Database ID Release 43400682 Reactome, http://www.reactome.org ReactomeREACT_19354 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01 The cytoplasmic tails of plexins have two domains, C1 and C2, which are highly conserved and act as GAP for small GTPases like Rac1. Active Rac1 binds directly to a binding domain of Plexin-B1 in the linker region between C1 and C2. The functional consequence of the plexin-B1/Rac interaction is not understood but this binding might sequester Rac1 away from p21-activated kinase (PAK). Plexin-B1 can compete with PAK for binding to active Rac and this competition results in the ability of plexin-B1 to inhibit Rac-induced PAK activation. RAC1-GTP