LARG and PDZ-RhoGEF Sema4D:pPlexin-B1:ErbB2:Rac1:Rnd1 Sema4D:Plexin-B1:Rac-Rnd1:LARG/PDZ-RhoGEF LARG and PDZ-RhoGEF binds to Plexin-B1 Authored: Garapati, P V, 2009-03-23 09:59:28 Edited: Garapati, P V, 2009-03-23 10:00:07 Plexin-B1 activates RhoA and induces growth cone collapse and and cytoskeletal reorganization through Rho-specific guanine nucleotide exchange factors PDZ-RhoGEF and leukemia-associated RhoGEF (LARG). Plexin-B1 directly interacts with PDZ-RhoGEF through its c-terminal PDZ domain binding motif. It has been suggested that Rnd1, which binds to the cytoplasmic part of plexin-B1, can promote the interaction between plexin-B1 and PDZ-RhoGEF. The PDZ domain of LARG is directly involved in the interaction with the c-terminal sequence of Plexin-B1. Pubmed12196628 Pubmed12220504 Pubmed12730235 Pubmed15210733 Reactome Database ID Release 43416594 Reactome, http://www.reactome.org ReactomeREACT_19153 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01