Fibrillins:MFAP2,MFAP5:Tropoelastin aggregate Tropoelastin aggregate Fibrilins:MFAP2,MFAP5 Tropoelastin associates with microfibrils Authored: Jupe, S, 2012-04-30 Edited: Jupe, S, 2012-11-12 Elastin, the highly insoluble core protein of elastic fibers, is secreted as a soluble protein monomer referred to as tropoelastin. Under physiological conditions the monomers phase separate and coalesce into spherical packages (Clarke et al. 2006), a process known as coacervation. Packages of accumulated elastin are delivered to fibrillin-based fibres in a mechanism that is correlated with cell migration during embryonic development (Czirok et al. 2006). A transglutaminase cross-link between domain 4 of tropoelastin and domain 16 of fibrillin-1 may stabilize initial deposition (Clarke et al. 2005). Elastin is subsequently cross linked by members of the lysyl oxidase family via lysine residues, resulting in mature, insoluble fibres (Sato et al. 2007, Wise & Weiss 2009). Pubmed16042404 Pubmed16331676 Pubmed16906757 Pubmed17459412 Pubmed18468477 Reactome Database ID Release 432129353 Reactome, http://www.reactome.org ReactomeREACT_150146 Reviewed: Muiznieks, Lisa, 2012-11-02