Fibrillins:MFAP2,MFAP5:Tropoelastin aggregate Elastic fibre Elastin cross-linking by lysyl oxidase Authored: Jupe, S, 2012-04-30 EC Number: 1.4.3.13 Edited: Jupe, S, 2012-11-12 Pubmed16906757 Pubmed16909208 Pubmed6123066 Reactome Database ID Release 432129375 Reactome, http://www.reactome.org ReactomeREACT_150459 Reviewed: Muiznieks, Lisa, 2012-11-02 Soluble monomers of tropoelastin are cross-linked by the oxidative deamination of lysine residues, catalyzed by lysyl oxidase (LOX). The first step in the cross linking reaction is the oxidative formation of the delta-aldehyde, known as alpha aminoadipic semialdehyde or allysine (Partridge 1963). Subsequent spontaneous reactions lead to the formation of cross-links through dehydrolysinonorleucine and allysine aldol, a trifunctional cross-link dehydromerodesmosine and two tetrafunctional cross-links desmosine and isodesmosine (Lucero & Kagan 2006), which are unique to elastin.