Fibulins Elastic fibre Elastic fibre:Fibulins Fibulin binds elastic fibres Authored: Jupe, S, 2012-04-30 Edited: Jupe, S, 2012-11-12 Fibulins are a family of 7 genes encoding calcium binding glycoproteins with distinct roles in elastogenesis. They are essential for elastic fibre formation, having a role in regulating and organising tropoelastin formation (Yanagisawa & Davis 2010). Fibulins 1-5 all bind elastin (Roark et al. 1995, Sasaki et al. 1999, Kobayashi et al. 2007). Fibulins 2, 4, 5 and 7 also bind fibrillin (Reinhardt et al. 1996, El Hallous et al. 2007, de Vega et al. 2007). Fibulin 6 has a role in the formation of the cleavage furrow during cytokinesis but its binding partners are unclear (Xu & Vogel 2011). Pubmed10544250 Pubmed17255108 Pubmed17324935 Pubmed17699513 Pubmed20236620 Pubmed21966563 Pubmed7534784 Pubmed8702639 Reactome Database ID Release 431592387 Reactome, http://www.reactome.org ReactomeREACT_150243 Reviewed: Muiznieks, Lisa, 2012-11-02