TGF-beta-1:LAP1:LAP1-binding integrins LAP1 binding-integrins TGF-beta-1:LAP1 Latent TGF-beta-1 binds integrins Authored: Jupe, S, 2012-04-30 Edited: Jupe, S, 2012-11-12 Pubmed10025398 Pubmed11970960 Pubmed12358597 Pubmed12415008 Pubmed16877343 Pubmed9725916 Reactome Database ID Release 432395320 Reactome, http://www.reactome.org ReactomeREACT_150434 Reviewed: Muiznieks, Lisa, 2012-11-02 The LAPs of TGF beta-1 and TGF beta-3 contain RGD sequences near the carboxyl termini that are bound by RGD binding integrins. The TGF beta-1 form of LAP (LAP1) binds the integrins alphaVBeta1 (Munger et al. 1998), alphaVBeta3 (Ludbrook et al. 2003), alphaVBeta5 (Munger et al. 1998), alphaVBeta6 (Munger et al. 1999, Araya et al. 2006), alphaVBeta8 (Mu et al. 2002, Araya et al. 2006) and alpha8Beta1 (Lu et al. 2002). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF beta activation.