LAP3-binding integrins TGF-beta-3:LAP3:LAP3-binding integrins TGF-beta-3:LAP3 Latent TGF-beta-3 binds integrins Authored: Jupe, S, 2012-04-30 Edited: Jupe, S, 2012-11-12 Pubmed12358597 Pubmed21646718 Reactome Database ID Release 432396029 Reactome, http://www.reactome.org ReactomeREACT_150337 Reviewed: Muiznieks, Lisa, 2012-11-02 The LAPs of TGF-beta1 and TGF-beta3 contain RGD sequences near the carboxyl termini that are bound by RGD-binding integrins. LAP3 binds alphaVBeta1, 3, 5 and 6 (Ludbrook et al. 2003) and 8 (Kitamura et al. 2011). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF-beta activation.