Phosphorylation of LIMK-1 by PAK Authored: Garapati, P V, 2009-03-23 09:59:28 EC Number: 2.7.11 Edited: Garapati, P V, 2009-03-23 10:00:07 LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. LIMK is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop. Pubmed10559936 Pubmed11276226 Reactome Database ID Release 43399952 Reactome, http://www.reactome.org ReactomeREACT_19221 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01