SEMA4D:CD72 complex SEMA4D interacts with CD72 Authored: Garapati, P V, 2009-03-23 09:59:28 Edited: Garapati, P V, 2009-03-23 10:00:07 In the immune system, Sema4D/CD100 binds CD72 to mediate B-cell-B-cell, B-cell-T-cell and T-cell-dendritic cell interactions and there by regulates B-cell and T-cell activation. In B-cells, this interaction directs the dissociation of SHP-1 from the CD72 cytoplasmic domain and enhances their activation.<br> Pubmed11114375 Pubmed12882840 Reactome Database ID Release 43373748 Reactome, http://www.reactome.org ReactomeREACT_19336 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01