Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation Dimerization of p-IRF7 TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation Translocation of p-IRF7:p-IRF7 to nucleus PathwayStep6759 PathwayStep6758 PathwayStep6757 PathwayStep6760 PathwayStep6761 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Authored: Shamovsky, V, 2010-08-25 Edited: Shamovsky, V, 2010-11-15 In plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and IRAKs and translocates to the nucleus upon phosphorylation (Kawai et al 2004; Uematsu et al 2005).<p> TLR7/8 signaling was shown to induce IRF5 activation along with IRF7 [Schoenemeyer et al 2005], while IRF8 [Tsujimura H et al 2004] and IRF1 were reported to be implicated in TLR9 signaling. Pubmed11070172 Pubmed15153500 Pubmed15361868 Pubmed15767370 Pubmed16214811 Pubmed16497588 Reactome Database ID Release 43975110 Reactome, http://www.reactome.org ReactomeREACT_25120 Reviewed: Gillespie, ME, 2010-10-29