Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex TRAF6 binds MEKK1 PathwayStep6755 PathwayStep6745 PathwayStep6750 PathwayStep6700 MAP kinase activation in TLR cascade TAK1 activates NFkB by phosphorylation and activation of IKKs complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Authored: Shamovsky, V, 2010-08-25 Edited: Shamovsky, V, 2010-11-15 Pubmed18794297 Pubmed22511786 Reactome Database ID Release 43975138 Reactome, http://www.reactome.org ReactomeREACT_25024 Reviewed: Gillespie, ME, 2010-10-29 TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1. PathwayStep3439 PathwayStep3485