Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex MyD88 interacts with the activated TLR receptor 7, 8 or 9 PathwayStep6736 PathwayStep6735 PathwayStep6738 PathwayStep6737 PathwayStep6739 PathwayStep6740 PathwayStep6741 PathwayStep6742 PathwayStep6743 PathwayStep6756 PathwayStep6762 PathwayStep6744 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome Authored: de Bono, B, 2005-08-16 10:54:15 Edited: Shamovsky, V, 2010-11-15 Pubmed15276183 Pubmed16497588 Pubmed18652679 Pubmed20237413 Reactome Database ID Release 43975155 Reactome, http://www.reactome.org ReactomeREACT_25222 Reviewed: Gillespie, ME, 2010-10-29 Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.