TRIF:activated TLR3/TLR4 complex recruits RIP1 K63-linked ubiquitination of RIP1 bound to the activated TLR complex Nemo subunit of IKK complex binds polyubiquinated RIP1 PathwayStep6717 PathwayStep6715 PathwayStep6716 IKK complex recruitment mediated by RIP1 Authored: Shamovsky, V, 2010-06-01 Edited: Shamovsky, V, 2010-11-15 Pubmed14530355 Pubmed16115877 Pubmed16603398 Reactome Database ID Release 43937041 Reactome, http://www.reactome.org ReactomeREACT_25374 Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways [Ea et al. 2006]. Poly(I-C) treatment stimulated the recruitment of RIP1, TRAF6, and TAK1 to the TLR3 receptor complex in human embryonic kidney HEK293 transfected with FLAG-tagged TLR3 [Cusson-Hermance et al. 2005]. RIP1 was shown to be dispensable for TRIF-dependent activation of IRF3, which occurs in a TRIF/TBK1/IKKi-dependent manner [Cusson-Hermance et al. 2005, Sato et al. 2003] Reviewed: Fitzgerald, Katherine A, 2012-11-13 Reviewed: Gillespie, ME, 2010-11-30