TLR3/4-induced ripoptosome assembly Caspase-8 processing RIP3 binds TRIF to mediate necroptosis PathwayStep6719 PathwayStep6721 PathwayStep6720 TRIF-mediated programmed cell death Authored: Shamovsky, V, 2012-05-15 Edited: Shamovsky, V, 2012-11-19 Pubmed12181749 Pubmed14739303 Pubmed15814722 Pubmed20019748 Pubmed21737329 Pubmed21737330 Pubmed22421964 Reactome Database ID Release 432562578 Reactome, http://www.reactome.org ReactomeREACT_150361 Reviewed: Fitzgerald, Katherine A, 2012-11-13 TLR3 and -4 trigger TRIF-dependent programmed cell death in various human and mouse cells [Kalai M et al 2002; Han KJ et al 2004; Kaiser WJ and Offermann MK 2005; Estornes Y et al 2012; He S et al 2011]. Apoptosis is a prevalent form of programmed cell death and is mediated by the activation of a set of caspases. In addition to apoptosis, TLR3/TLR4 activation induces RIP3-dependent necroptosis. These two programmed cell-death pathways may suppress each other. When the caspase activity is impaired or inhibited, certain cell types switch the apoptotic death program to necroptosis in response to various stimuli (TNF, Fas, viral infection and other stress stimuli) [Kalai M et al 2002; Weber A et al 2010; Feoktistova M et al 2011, Tenev et al 2011].