Integrin alpha3beta1 Integrin alpha3beta1:Laminin-5 Laminin-5 Interaction of integrin alpha3beta1 with Laminin-5 Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Pubmed11964076 Reactome Database ID Release 43216048 Reactome, http://www.reactome.org ReactomeREACT_13569 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 The alpha3beta1 (VLA-3) is known as a promiscuous receptor, as it functions as a receptor for various ECM proteins including laminins, fibronectin and collagen and for intercellular adhesion through interaction with other integrins. The alpha3beta1 is of particular interest, as its expression is associated with melanoma progression. Among the laminin isoforms Laminin-5 binds to VLA-3 with high affinity and promotes melanoma cell migration.