VLA-4 VLA-4:VCAM-1 VCAM-1interacts with VLA-4 Authored: de Bono, B, 2007-07-08 12:58:15 Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. LFA-1 interacts with ICAMs 1-3 that are typically expressed on other immune system cells. ICAM-4 also interacts with LFA-1, and is known to be expressed on telencepahlic neurons.<p><p>VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4).<p><p>To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change.<p><p>Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion. Pubmed11857637 Pubmed7531291 Reactome Database ID Release 43198941 Reactome, http://www.reactome.org ReactomeREACT_11161 Reviewed: Trowsdale, J, 2007-08-06 19:33:04