VLA-4 VLA-4:Osteopontin complex Interaction of integrin alpha4beta1 with Osteopontin Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Osteopontin (OPN) provides an adhesive matrix for endothelial and smooth muscle cells during remodeling of the vascular wall following injury. The alpha4beta1 integrin is expressed on leukocytes, differentiated vascular smooth muscle cells and tumor cells. The alpha4beta1 integrin has been shown to mediate leukocyte attachment to OPN. Pubmed9547293 Reactome Database ID Release 43265424 Reactome, http://www.reactome.org ReactomeREACT_13810 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37