Thrombospondin-1 trimer VLA-4 VLA-4:Thrombospondin-1 complex Interaction of integrin alpha4beta1 with Thrombospondin-1 Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Pubmed11980922 Pubmed15292271 Reactome Database ID Release 43265421 Reactome, http://www.reactome.org ReactomeREACT_13516 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 Thrombospondin-1 (TSP1) is an extracellular matrix glycoprotein that modulates cell adhesion, growth, motility, differentiation, and survival. TSP1 interacts with cells via a number of receptors, including several integrins. Alpha4beta1 integrin binds to the N-terminal pentraxin modules of TSP1 and stimulates chemotaxis and modulates T cell behavior both positively and negatively.