PathwayStep7271 Cellular responses to stress Authored: Matthews, L, 2012-05-20 Cells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissues to modulate molecular processes in response to such external stresses is essential to the maintenance of tissue homeostasis (Kultz 2005). Edited: Matthews, L, 2012-05-20 GENE ONTOLOGYGO:0033554 Pubmed15709958 Reactome Database ID Release 432262752 Reactome, http://www.reactome.org ReactomeREACT_120956 Reviewed: D'Eustachio, P, 2012-05-20 Cellular response to hypoxia