PathwayStep7270 Cellular response to hypoxia Authored: May, B, 2012-05-20 Edited: Matthews, L, 2012-05-20 GENE ONTOLOGYGO:0071456 Oxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one aspect of cellular responses to oxygen (Semenza 2004), the role of hypoxia-inducible factor in regulating cellular transcriptional responses to changes in oxygen availability. Pubmed15304631 Reactome Database ID Release 432262749 Reactome, http://www.reactome.org ReactomeREACT_121311 Reviewed: D'Eustachio, P, 2012-05-20 Regulation of Hypoxia-inducible Factor (HIF) by Oxygen