Integrin alpha7beta1:Laminin-1 Integrin alpha7beta1 Laminin-1 Interaction of integrin alpha7beta1 with Laminin-1 Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Of the 12 alpha integrin subunits associated with beta1 integrin, mainly alpha7, alpha3 and alphaV are present in skeletal muscles. The alpha7beta1 integrin is a laminin receptor that serves as a transmembrane link and signal transduction mechanism between the extracellular matrix and muscle fiber. The alpha7beta1 integrin plays an important role in vascular development and also in the recruitment of cerebral vascular smooth muscles cells. Alpha7beta1 binds to laminin-1, which is one of the major laminin isoforms expressed in the developing and adult vasculature. Pubmed10910772 Pubmed11054877 Pubmed16003770 Pubmed17901369 Reactome Database ID Release 43216054 Reactome, http://www.reactome.org ReactomeREACT_13613 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37