Degradation multiubiquitinated Cyclin A Association of Cyclin A with the APC/C Ubiquitination of Cyclin A by APC/C:Cdc20 complex PathwayStep7273 PathwayStep7274 PathwayStep7272 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Authored: Lorca, T, Castro, A, 2006-01-26 00:00:00 Cyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas and Bartek, 2004). Cyclin A is initially degraded early in mitosis by APC/C:Cdc20 when the spindle checkpoint is still active and degradation of securin and cyclin B is inhibited. Edited: Matthews, L, 2006-01-30 00:00:00 GENE ONTOLOGYGO:0031145 Pubmed11285280 Pubmed15577895 Reactome Database ID Release 43174184 Reactome, http://www.reactome.org ReactomeREACT_6850 Reviewed: Peters, JM, 2006-03-27 22:55:09