FN1 dimer Integrin alpha8beta1:Fibronectin Integrin alpha8beta1 Interaction of integrin alpha8beta1 with Fibronectin Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Integrins can influence cell survival in several ways. The integrin alpha8 subunit forms a heterodimer exclusively with beta1 subunit and is expressed in mesenchymal cells. Alpha8beta1 recognizes the tripeptide sequence RGD in several ECM proteins including fibronectin, tenascin and vitronectin. Alpha8beta1 integrin promotes cell survival through adhesion to fibronectin and may play a role in the continued survival of matrix producing cells during fibrosis mediated by PI3 kinase pathway. Pubmed15721307 Pubmed7626807 Reactome Database ID Release 43216059 Reactome, http://www.reactome.org ReactomeREACT_13465 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37