Formation of HIF-alpha:ARNT (HIF-1beta) Heterodimer Formation of HIF:CBP:p300 Complex at Promoters Translocation of HIF-alpha from Cytosol to Nucleus Expression of Carbonic Anhydrase IX (CA9) Expression of VEGF (isoform 1) Expression of Erythropoietin (EPO) PathwayStep7264 PathwayStep7265 PathwayStep7266 PathwayStep7267 PathwayStep7268 PathwayStep7263 Regulation of Gene Expression by Hypoxia-inducible Factor Authored: May, B, 2011-03-09 Edited: May, B, 2011-03-09 HIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) is translocated to the nucleus, possibly by two pathways: importin 4/7 (Chachami et al. 2009) and importin alpha/beta (Depping et al. 2008). Once in the nucleus HIF-alpha heterodimerizes with HIF-beta (ARNT) (Wang et al. 1995, Jiang et al. 1996, Tian et al. 1997, Gu et al. 1998, Erbel et al. 2003) and recruits CBP and p300 to promoters of target genes (Ebert and Bunn 1998, Kallio et al. 1998, Ema et al. 1999, Gu et al. 2001, Dames et al. 2002, Freedman et al. 2002). Pubmed10202154 Pubmed11063749 Pubmed11959977 Pubmed11959990 Pubmed14668441 Pubmed18187047 Pubmed19788888 Pubmed7539918 Pubmed8663540 Pubmed9000051 Pubmed9632793 Pubmed9822602 Pubmed9840812 Reactome Database ID Release 431234158 Reactome, http://www.reactome.org ReactomeREACT_121092 Reviewed: Rantanen, Krista, 2012-05-19