Integrin alpha9beta1 Integrin alpha9beta1:Osteopontin Interaction of integrin alpha9beta1 with Osteopontin Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Osteopontin is involved in cell adhesion, chemoattraction and immunomodulation. Osteopontin contains several interesting structural domains. Several integrin receptors interact with the RGD domain. There are two conserved thrombin cleavage sites in osteopontin and the adhesive interactions may be regulated by the thrombin cleavage. The thrombin cleaved NH3-terminal fragment of osteopontin containing the RGD domain acts as a ligand for integrin alpha9beta1. Unlike the most of the integrin receptors alpha9beta1 does not bind the RGD domain but interacts with a sequence ‘SVVYGLR’ in the N-terminal fragment of osteopontin. Pubmed10593924 Pubmed8910476 Reactome Database ID Release 43216066 Reactome, http://www.reactome.org ReactomeREACT_13751 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37