Angiomotins AMOT:YAP1 AMOT proteins bind YAP1 AMOT (130 KDa isoform), AMOTL1, and AMOTL2 can each bind YAP1 and sequester it in the cytosol. This interaction is not dependent on YAP1 phosphorylation and may thus be a means of negatively regulating YAP activity in addition to the ones dependent on Hippo pathway-dependent phosphorylation. AMOT - YAP1 binding is dependent on sequence motifs in the amino terminal portions of the AMOT proteins (and that are absent from the AMOT 80 KDa isoform, which does not bind YAP1) (Wang et al. 2010; Chan et al. 2011). Authored: D'Eustachio, P, 2012-02-03 Edited: D'Eustachio, P, 2012-01-06 Pubmed21187284 Pubmed21224387 Reactome Database ID Release 432028724 Reactome, http://www.reactome.org ReactomeREACT_118701 Reviewed: Sudol, M, 2012-02-03