Integrin alpha1beta1:Type IV collagen:Mg++ Integrin alpha1beta1 Type IV collagen Interaction of integrin alpha1beta1 with Type IV collagen Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Pubmed10963992 Pubmed15451466 Pubmed16623929 Pubmed17603494 Reactome Database ID Release 43216040 Reactome, http://www.reactome.org ReactomeREACT_13656 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 The alpha1/beta1 integrin, also known as very late antigen (VLA)-1, is mostly expressed on smooth muscle cells and are also found on fibroblasts, osteoblasts, chondrocytes, endothelial cells and lymphocytes. They have a specific inserted domain or I domain as a part of their alpha subunit. This I domain is responsible for the recognition and interaction with collagen molecules in the extracellular matrix (ECM). VLA-1 primarily binds to type IV but also to type I collagen. By outside-in transmembranal signaling to the interior of the cell, it mediates adhesion, migration, proliferation, remodeling of the ECM, and cytokine secretion by endothelial cells, mesangial cells, fibroblasts, and immunocytes.