Dephosphorylation of STAT1 by SHP2 Dephosphorylation of JAK1 by SHP1 Dephosphorylation of TYK2 by PTP1B UBP43 binds IFNAR2 and prevents JAK1 interaction Inhibition of JAK kinase activity by SOCS1/3 PathwayStep7060 PathwayStep7059 PathwayStep7057 PathwayStep7058 PathwayStep7056 Regulation of IFNA signaling Authored: Garapati, P V, 2010-07-07 Edited: Garapati, P V, 2010-07-07 GENE ONTOLOGYGO:0060338 Pubmed10526574 Pubmed16311601 Pubmed16710296 Reactome Database ID Release 43912694 Reactome, http://www.reactome.org ReactomeREACT_25216 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 There are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation of JAK and STAT by SHP protein phosphatases, inhibition of STAT function in the nucleus by protein inhibitors of activated STATs (PIAS) proteins, inhibition of tyrosine kinase activity of JAKs by SOCS as well as inhibition of JAK and IFNAR2 interaction by UBP43 are few of the negative regulation mechanisms in controling type I IFN signaling.