PIAS1 binds p-STAT1 dimer Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP SOCS-1 and SOCS-3 binds to p-JAK2 Dephosphorylation of JAKs by PTPs PathwayStep7076 PathwayStep7075 PathwayStep7074 PathwayStep7077 Regulation of IFNG signaling At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade. Authored: Garapati, P V, 2010-06-08 Edited: Garapati, P V, 2010-06-08 GENE ONTOLOGYGO:0060334 Pubmed10526574 Pubmed12645661 Pubmed18031232 Reactome Database ID Release 43877312 Reactome, http://www.reactome.org ReactomeREACT_24980 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17