PathwayStep6999 PathwayStep7005 DAI mediated induction of type I IFNs Cytosolic sensors of pathogen-associated DNA Authored: Shamovsky, V, 2011-09-21 Edited: Shamovsky, V, 2012-02-23 GENE ONTOLOGYGO:0032481 Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), leucine-rich repeat flightless interacting protein-1 (Lrrfip1), DExD/H box helicases (DHX9 and DHX36), and the IFN-inducible protein IFI16.<p>Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin (IL)-1beta and IL-18. This pathway is mediated by AIM2. Pubmed21533068 Reactome Database ID Release 431834949 Reactome, http://www.reactome.org ReactomeREACT_118823 Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- STING mediated induction of type 1 IFN