PIN1 mediated IRF3 degradation Interaction of PIN1 with p-IRF3 CYLD mediated deubiquitination of RIG-I Inhibition of RIG-I/MDA5 signaling by ATG5-ATG12 conjugate RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 Recruitment of AIP4 and K-48 ubiquitination of MAVS/IPS-1 Interaction of PCBP2 with MAVS/IPS-1 NLRC5 interacts with RIG-I/MDA5 and inhibit IPS-1 binding TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination ISGylation of RIG-I NLRX1 inhibits IPS-1-RIG-I interaction. Negative regulation of RIG-I/MDA5 signaling by TRIAD3A Negative regulation of RIG-I/MDA5 signaling by DUBA PathwayStep6964 PathwayStep6952 PathwayStep6963 PathwayStep6962 PathwayStep6961 PathwayStep6960 PathwayStep6955 PathwayStep6956 PathwayStep6953 PathwayStep6954 PathwayStep6959 PathwayStep6957 PathwayStep6958 Negative regulators of RIG-I/MDA5 signaling As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5. Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-02 GENE ONTOLOGYGO:0032480 Pubmed18549796 Pubmed18703349 Reactome Database ID Release 43936440 Reactome, http://www.reactome.org ReactomeREACT_25271 Reviewed: Kawai, T, Akira, S, 2010-10-30