Interaction of DAP12 and CLM7 Interaction of SIGLEC14/15/16 and DAP12 Interaction of DAP12 and IREM2 Interaction of DAP12 and TREM1 Interaction of DAP12 and TREM2 DAP12 interacts with NKG2C Interaction of DAP12 and NKG2D Interaction of DAP12 and NKp44 Interaction of DAP12 and KIR2DS4 Interaction of DAP12 and KIR2DS5 Interaction of DAP12 and KIR3DS1 Interaction of DAP12 and MDL-1 Dimerization of DAP12 Interaction of DAP12 and KIR2DS1 Interaction of DAP12 and KIR2DS2 Interaction of DAP12 and SIRP beta PathwayStep4823 PathwayStep7020 PathwayStep7021 PathwayStep7019 PathwayStep7039 PathwayStep7008 PathwayStep7009 PathwayStep7010 PathwayStep7012 PathwayStep7011 PathwayStep7014 PathwayStep7013 PathwayStep7016 PathwayStep7015 PathwayStep7018 PathwayStep7017 PathwayStep7007 DAP12 signaling DAP12 interactions Authored: Garapati, P V, 2012-05-25 DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cells. It mediates signalling for multiple cell-surface receptors expressed by these cells, associating with receptor chains through complementary charged transmembrane amino acids that form a salt-bridge in the context of the hydrophobic lipid bilayer (Lanier et al. 1998). DAP12 homodimers associate with a variety of receptors expressed by macrophages, monocytes and myeloid cells including TREM2, Siglec H and SIRP-beta, as well as activating KIR, LY49 and the NKG2C proteins expressed by NK cells. DAP12 is expressed at the cell surface, with most of the protein lying on the cytoplasmic side of the membrane (Turnbull & Colonna 2007, Tessarz & Cerwenka 2008). Edited: Garapati, P V, 2012-05-25 Pubmed15884055 Pubmed17220916 Pubmed18192027 Pubmed19120482 Pubmed9490415 Reactome Database ID Release 432172127 Reactome, http://www.reactome.org ReactomeREACT_147694 Reviewed: Lanier, Lewis L, 2012-08-09