DAI recruits RIP1 and RIP3 RIP1 facilitates IKK complex phosphorylation PathwayStep6996 PathwayStep6997 RIP-mediated NFkB activation via DAI Authored: Shamovsky, V, 2011-09-21 Edited: Shamovsky, V, 2012-02-23 Overexpression of human or murine DAI in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are implicated in DAI-induced NFkB activation (Rebsamen M et al 2009; Kaiser WJ et al 2008). Pubmed18941233 Pubmed19590578 Reactome Database ID Release 431810476 Reactome, http://www.reactome.org ReactomeREACT_118563 Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- PathwayStep3438 PathwayStep3437 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex Released NFkB complex is transported to nucleus