dsDNA:AIM2:ASC cluster binds procaspase-1 dsDNA:AIM2 clusters bind ASC AIM2 oligomerizes AIM2 binds dsDNA PathwayStep6909 PathwayStep6908 PathwayStep6911 PathwayStep6910 The AIM2 inflammasome AIM2 is a member of the PYHIN or HIN200 family. It has a C-terminal HIN domain which can bind double-stranded DNA (dsDNA) and a PYD domain that can bind ASC via a PYD-PYD interaction. In cells expressing procaspase-1, The interaction of AIM2 with ASC leads to recruitment of procaspase-1 forming the ASC pyroptosome which induces pyroptotic cell death by generating active caspase-1. Data from AIM2 deficient mice indicates that the AIM2 inflammasome is a nonredundant sensor for dsDNA that regulates the caspase-1-dependent maturation of IL-1beta and IL-18 (Rathinam et al. 2010, Hornung & Latz, 2009). Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Pubmed20098460 Pubmed20303873 Pubmed20351692 Reactome Database ID Release 43844615 Reactome, http://www.reactome.org ReactomeREACT_75777 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06