IRF3:CBP/p300 complex binds the promoters of IFN-beta Interaction of CBP/p300 with p-IRF3 dimer Phosphorylation and release of IRF3/IRF7 Recruitment of IRF3/7  Translocation of phosphorylated IRF3/7 dimers into nucleus Dimerization of Phospho IRF3 or phospho IRF7 Recruitment of TRAF3 to IPS-1 TBK1/IKK epsilon complex interacts with IPS-1 bound TRAF3 PathwayStep6930 PathwayStep6924 PathwayStep6925 PathwayStep6926 PathwayStep6927 PathwayStep6928 PathwayStep6929 PathwayStep6931 PathwayStep6932 Expression of IFN-beta TRAF3-dependent IRF activation pathway Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-02 IPS-1/MAVS/Cardif/VISA with its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the RIG-I/MDA5 signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7. Pubmed16306936 Pubmed17190786 Reactome Database ID Release 43918233 Reactome, http://www.reactome.org ReactomeREACT_25026 Reviewed: Kawai, T, Akira, S, 2010-10-30