Interaction of MEKK1 with TRAF6 Activation of IKK by MEKK1 PathwayStep6950 PathwayStep6949 TRAF6 mediated NF-kB activation Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-02 Pubmed18984593 Reactome Database ID Release 43933542 Reactome, http://www.reactome.org ReactomeREACT_24969 Reviewed: Kawai, T, Akira, S, 2010-10-30 The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I/MDA5 pathway is largely unknown. According to the study done by Yoshida et al RIG-I/IPS-1 pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kB and MAP Kinases for optimal induction of type I IFNs. PathwayStep3438 PathwayStep3437 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex Released NFkB complex is transported to nucleus