Integrin alphaVbeta3 Integrin alphaVbeta3:Bone sialoprotein 2 Interaction of integrin alphaVbeta3 with Bone sialoprotein 2 Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Integrin alphaVbeta3 receptor has been implicated in various physiological and pathological responses, including bone density, angiogenesis, apoptosis, tumor growth and metastasis. <br>Bone sialoprotein (BSP) is a significant component of the bone extracellular matrix and plays an important role in bone resorption and osteoclast formation. BSP is considered as an important physiological ligand of alphaVbeta3 for osteoclast adhesion in bone development and mineralization. Pubmed10640428 Reactome Database ID Release 43265427 Reactome, http://www.reactome.org ReactomeREACT_13402 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37