fibrin multimer Integrin alphaDbeta2:fibrin multimer:Mg++ Integrin alphaDbeta2 Interaction of integrin alphaDbeta2 with fibrin Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Integrin alphaDbeta2 is a member of the beta2 family. It is expressed poorly on peripheral blood leukocytes but strongly on macrophages. alphaDbeta2 has the ability to interact with multiple ligands, including many ECM proteins. The interaction of beta2 integrins with ligands is mediated by their I-domains of the alpha subunits. The alphaD I-domain mediates the interaction with the ECM protein fibrinogen. Pubmed10438935 Pubmed16239428 Reactome Database ID Release 43216069 Reactome, http://www.reactome.org ReactomeREACT_13787 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37