Integrin alphaIIb beta3 VWF multimer Integrin alphaIIbbeta3:VWF multimer Interaction of integrin alphaIIbbeta3 with von Willebrand factor Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Integrin alphaIIbbeta3 (glycoprotein IIb-IIIa, GP IIb-IIIa) is one of the major platelet receptor that is involved in aggregation and adhesion of platelets. In resting stage alphaIIbbeta3 is inactive and does not interact with its ligands but upon activation or vascular injury it binds to the ECM protein von Willebrand factor (vWf) and stimulate the platelet aggregation. Pubmed11713259 Pubmed12585966 Reactome Database ID Release 43216072 Reactome, http://www.reactome.org ReactomeREACT_13780 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37