Integrin alphaVbeta3 Integrin alphaVbeta3:Vitronectin Interaction of integrin alphaVbeta3 with vitronectin Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Integrin alphaVbeta3 a vitronectin receptor is highly expressed on the osteoclasts, bone resorbing cells and is upregulated during vascular damage, during angiogenesis and also in certain type of malignancies. It binds to vitronectin by recognizing the conserved RGD sequence with in the N-ter region of vitronectin. This integrin plays an important role in signal transduction and regulating osteoclast function. Pubmed17968485 Pubmed9251239 Reactome Database ID Release 43216076 Reactome, http://www.reactome.org ReactomeREACT_13634 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37