TLR1/2 ligand binds to CD14 TLR1:TLR2 is recruited to ligand:CD14 PathwayStep6799 PathwayStep6796 PathwayStep6800 MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Authored: D'Eustachio, P, Gay, NJ, Gale M, Jr, Zwaginga, JJ, 2006-04-19 04:09:58 Edited: Shamovsky, V, 2012-11-06 GENE ONTOLOGYGO:0034130 Pubmed12975352 Reactome Database ID Release 43168179 Reactome, http://www.reactome.org ReactomeREACT_8005 Reviewed: D'Eustachio, P, 2006-07-03 21:35:13 TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).