TLR6/2 ligand associates with CD14 and CD36 within lipid rafts TLR6:TLR2 is recruited to ligand:CD14:CD36 PathwayStep6796 PathwayStep6803 PathwayStep6802 MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Authored: D'Eustachio, P, Gay, NJ, Gale M, Jr, Zwaginga, JJ, 2006-04-19 04:09:58 Edited: Shamovsky, V, 2012-11-19 GENE ONTOLOGYGO:0002224 Pubmed14977973 Reactome Database ID Release 43168188 Reactome, http://www.reactome.org ReactomeREACT_8006 Reviewed: D'Eustachio, P, 2006-07-03 21:35:13 TLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recognizing peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides. In particular, TLR6 appears to participate in discriminating the subtle differences between dipalmitoyl and tripalmitoyl cysteinyl residues (Okusawa et al. 2004).