IGF1/2:IGF1R IGF1R IGF1/2 binds IGF1R Authored: May, B, 2012-07-07 Edited: May, B, 2012-07-07 Either IGF1 (IGF-I) or IGF2 (IGF-II) can bind the type 1 insulin-like growth factor receptor (IGF1R) (Casella et al. 1986, LeBon et al. 1986, Maly and Luthi 1986, Cacieri et al. 1988, Steele-Perkins et al. 1988, Burgisser et al. 1991, Germain-Lee et al. 1992, Keyhanfar et al. 2007, Alvino et al. 2009, Alvino et al. 2011). IGF1R has similar affinities for IGF1 and IGF2 (Casella et al. 1986, Steele-Perkins et al. 1988). The binding sites for IGF1 and IGF2 are in a similar location on the alpha peptide of IGF1R but there are some differences in which residues of IGF1R interact with IGF1 vs. IGF2 (Keyhanfar et al. 2007, Alvino et al. 2009, Alvino et al. 2011). Pubmed1310594 Pubmed16981855 Pubmed1845984 Pubmed19139090 Pubmed22140443 Pubmed2839228 Pubmed2969892 Pubmed3011795 Pubmed3013881 Pubmed3019338 Reactome Database ID Release 432404200 Reactome, http://www.reactome.org ReactomeREACT_150464 Reviewed: Holzenberger, Martin, 2012-11-09 IGF1/2