IGF1/2:p-IGF1R:p-IRS1/2/4 IGF1/2:p-IGF1R:IRS1/2/4 IGF1/2:p-IGF1R phosphorylates IRS1/2/4 Authored: May, B, 2012-08-06 EC Number: 2.7.10 Edited: May, B, 2012-08-06 Phosphorylated IGF1R phosphorylates IRS1 (Siemeister et al. 1995, Xu et al. 1995, Takahashi et al. 1997, Rakatzi et al. 2006), IRS2 (Kim et al. 1998, Kim et al. 2004), and IRS4 (Fantin et al.1998, Karas et al. 2001, Cuevas et al. 2007) on numerous tyrosine residues. IRS4 is phosphorylated by IGF1R in HEK cells but not in primary muscle cells (Fantin et al. 1998, Schreyer et al. 2003). The phosphotyrosine resideus create binding sites for downstream effectors such as GRB2:SOS and PI3K. Pubmed11316748 Pubmed12639902 Pubmed14712218 Pubmed16754202 Pubmed17408801 Pubmed7876259 Pubmed8530377 Pubmed9003010 Pubmed9553137 Pubmed9832424 Pubmed9852124 Reactome Database ID Release 432428926 Reactome, http://www.reactome.org ReactomeREACT_150135 Reviewed: Holzenberger, Martin, 2012-11-09